Odion Ighalo (right) scored the second goal for Manchester United - who won the competition in 2017 - in Thursday's 5-0 win over Club Bruges
Manchester United have been drawn against Austrian league leaders LASK in the last 16 of the Europa League.
Fellow Premier League side Wolves will face Olympiakos, who knocked Arsenal out to reach this stage.
Scottish Premiership outfit Rangers will face former winners Bayer Leverkusen.
Five-time champions Sevilla face Roma and another Spanish-Italian duel sees Inter Milan, third in Serie A, up against Getafe.
- Istanbul Basaksehir v Copenhagen
- Olympiakos v Wolves
- Rangers v Bayer Leverkusen
- Wolfsburg v Shakhtar Donetsk
- Inter Milan v Getafe
- Sevilla v Roma
- Eintracht Frankfurt v Basel
- LASK v Manchester United
The matches are set to be played on 12 and 19 March.
-- Courtesy of BBC Sport